Abstract
In deze casuïstiek wordt een opvallend pijnlijke, ulceratieve dermatitis overeenstemmend met pyoderma gangrenosum beschreven bij een 2,5 jaar oude, intacte, vrouwelijke maltezer. De hond had een nasale stridor en vertoonde onregelmatige ulceraties met verheven inflammatoire randen op de lenden, staart en achterste ledematen. Er was geen respons op diverse antibiotica. Het histopathologisch beeld werd gekenmerkt door diepe kratervormige ulceraties met een uitgesproken neutrofiel infiltraat, onderliggend en aan de randen van de verzweringen. Een behandeling met enkel prednisolone (Kela Laboratories, Sint-Niklaas, Belgium) resulteerde in een complete regressie van de nasale symptomen en huidletsels.
Highlights
Pyoderma gangrenosum (PG) is a rare, destructive, reactive sterile inflammatory skin disease (Gross et al, 2005; Miller et al, 2013)
Canine PG has been associated with preceding polyarthritis in one dog (Bardagi et al, 2007), and considered idiopathic in two dogs (Simpson et al, 2013)
PG is diagnosed by compatible clinical features, with exclusion of other causes of ulcerative disease, and by supportive histopathology (Gross et al, 2005; Ruocco et al, 2009)
Summary
Pyoderma gangrenosum (PG) is a rare, destructive, reactive sterile inflammatory skin disease (Gross et al, 2005; Miller et al, 2013). Three cases have been reported in dogs in the peer-reviewed literature (Bardagi et al, 2007; Simpson et al, 2013). It is one of the group of neutrophilic dermatoses in dogs that includes subcorneal pustular dermatosis and Sweet’s syndrome. Reported effective treatments in the dog include oral prednisolone in conjunction with ciclosporin (Bardagi et al, 2007) or with azathioprine (Simpson et al, 2013). The clinical aspects of PG in a Maltese dog and the successful treatment with prednisolone alone are described
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