EEG source gravity center location changes after a single dose of atypical antipsychotics in healthy volunteers

Abstract

EEG source localization effects of 4 different novel atypical antipsychotics were compared with 2 conventional typical antipsychotics and a placebo in 14 male, right-handed normals (24.1±4.1 years). All subjects went through seven sessions. In each session, a subject received orally either 0.5-mg risperidone, 4-mg perospirone, 33-mg quetiapine, 1.25-mg olanzapine, 50-mg chlorpromazine, 1-mg haloperidol or placebo according to a single-blind, crossover, Latin-square design. EEG was recorded from 19 scalp-electrodes prior to as well as 2, 4 and 6 h after drug administration. Twenty-second artifact-free/subject/drug/time-point EEG were analyzed into FFT dipole approximation source models for seven frequency bands. Assuming the maximal effect would correspond to serum-concentration, 2 h after perospirone and quetiapine, 4 h after risperidone, olanzapine and chlorpromazine, and 6 h after haloperidol were chosen. Differences from pre-drug source gravity center locations (3D values) were compared using one-way repeated measures ANOVAs, then post-hoc LSD multiple comparisons were applied. The source gravity center of excitatory β3 frequency band (21.5–30 Hz) after perospirone was more right than after risperidone, olanzapine, chlorpromazine and placebo, while after quetiapine and haloperidol were more right than after olanzapine ( p<0.05). Our results suggest that the seven test drugs including placebo acted differently on neural populations after a single administration.