EEG power spectra parameterization and adaptive channel selection towards semi-supervised seizure prediction

Abstract

Background:The seizure prediction algorithms have demonstrated their potential in mitigating epilepsy risks by detecting the pre-ictal state using ongoing electroencephalogram (EEG) signals. However, most of them require high-density EEG, which is burdensome to the patients for daily monitoring. Moreover, prevailing seizure models require extensive training with significant labeled data which is very time-consuming and demanding for the epileptologists. Method:To address these challenges, here we propose an adaptive channel selection strategy and a semi-supervised deep learning model respectively to reduce the number of EEG channels and to limit the amount of labeled data required for accurate seizure prediction. Our channel selection module is centered on features from EEG power spectra parameterization that precisely characterize the epileptic activities to identify the seizure-associated channels for each patient. The semi-supervised model integrates generative adversarial networks and bidirectional long short-term memory networks to enhance seizure prediction. Results:Our approach is evaluated on the CHB-MIT and Siena epilepsy datasets. With utilizing only 4 channels, the method demonstrates outstanding performance with an AUC of 93.15% on the CHB-MIT dataset and an AUC of 88.98% on the Siena dataset. Experimental results also demonstrate that our selection approach reduces the model parameters and training time. Conclusions:Adaptive channel selection coupled with semi-supervised learning can offer the possible bases for a light weight and computationally efficient seizure prediction system, making the daily monitoring practical to improve patients’ quality of life.