EEG features in patients with different subtypes of prolonged and chronic endogenous manic-delusional states

Abstract

The purpose of the study. Analysis of the features of EEG spectral parameters in patients with polymorphic and monomorphic subtypes of prolonged and chronic endogenous manic-delusional states (PEMDS).Materials and methods. A clinical-neurophysiological study was carried out in 76 female patients with monomorphic (group 1, 34 patients) and polymorphic (group 2, 42 patients) subtypes of PEMDS, identified based on clinical-dynamic analysis.Results. In the group 1, compared with the group 2, there were significantly lower values of the spectral power of the pre-treatment EEG in most EEG leads and frequency sub-bands, which reflect a significant deficit in the brain inhibitory systems. In the group 2, the EEG slowdown (in the delta-frequency sub-band) after treatment course, was significantly more pronounced in the frontal-anterotemporal-central cortical zones of the left hemisphere, reflecting a greater increase of the neurophysiological processes of inhibition in these brain areas under the influence of treatment, which leads to an improvement in the clinical condition of patients.Conclusions. The revealed differences in the brain functional activity organization may mediate the features of the clinical picture and therapeutic response in patients with polymorphic and monomorphic subtypes of PEMDS.