Abstract
Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD. Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects.
Highlights
Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder affecting3–7% of school-age children [1]
Note: Arrows indicated increase or decrease of event-related potential (ERP) amplitude or event-related spectral perturbation (ERSP)/inter-trial coherence (ITC) in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). 1 p-values below are corrected for multiples comparisons (False Discovery Rate method)
In response to the Nogo stimulus, we found over posterior regions a lower P1-N2, with at the same latency a higher alpha power and lower alpha ITC in children with ADHD compared to TDC
Summary
Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder affecting3–7% of school-age children [1]. Brain Sci. 2017, 7, 167 impulsivity and hyperactivity It is associated with school difficulties and social impairment [2]. Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects
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