EEG based brain functional connectivity analysis for post-autoimmune encephalitis (AE) patients with epilepsy

Abstract

Autoimmune Encephalitis (AE) refers to a group of conditions that occur when the body’s immune system mistakenly attacks healthy brain cells, leading to inflammation of the brain. Seizures are a common symptom of AE and more than a third of patients experiencing seizures secondary to AE become epileptic over time. The objective of the present study is to identify biomarkers that can be used to identify those patients in whom AE will evolve into epilepsy. The bursts of abnormal electrical activity that occur during a seizure can be recorded by using Electroencephalography (EEG). In this work, common EEG (cEEG) and ambulatory EEG (aEEG) were recorded to compare the brain functional connectivity (FC) properties in post-AE patients with epilepsy patients and post-AE patients without epilepsy. The brain functional networks of spike waves were first constructed on the basis of Phase Locking Value (PLV). An analysis was then performed of the differences which existed in the FC properties of clustering coefficient, characteristic path length, global efficiency, local efficiency, and node degree between post-AE patients with epilepsy patients and post-AE patients without epilepsy. From the perspective of brain functional network analysis, post-AE patients with epilepsy showed a more complex network structure. Furthermore, the five FC properties have been found signification different, all FC property values of post-AE patients with epilepsy are higher than those of post-AE patients without epilepsy of cEEG and aEEG. Based on the extracted FC properties, five classifiers were used to classify them, and the results showed that all five FC properties could effectively distinguish between post-AE patients with epilepsy patients and post-AE patients without epilepsy in both cEEG and aEEG. These findings are potentially helpful for diagnosing whether a patient with AE will become epileptic.