Abstract
Substrate stiffness has been shown to be an important regulator of neural stem cell (NSC) fate commitment, but a full understanding of which processes are affected is still unclear. To elucidate this mechanism, we employed an unbiased transcriptomic study using RNA-sequencing on NSCs differentiating on soft versus stiff substrates within an early time window in which mechanical cues have the most influence on NSC fate commitment. We determined a large number of genes that are upregulated in NSCs differentiating on stiff substrates compared to those on soft substrates.
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