Abstract
In this work, the effect of brassinosteroids on the antitumor activity of classical cytostatic cisplatin in tumor cell lines A549 (human lung carcinoma) and Hep G2 (human hepatocellular carcinoma) was evaluated. Natural brassinosteroids 24-epibrassinolide and 28-homocastasterone, as well as their synthetic analogues (22S,23S)-24-epibrassinolide and (22S,23S)-28-homocastasterone were used. All four compounds with cisplatin inhibited the growth of cancer cells more effectively than cisplatin alone. Combinations with low concentrations of synthetic brassinosteroids were more effecient, and at 1 µM decreased the IC50 of cisplatin by almost 2 times. The results suggest a possible benefit of combinations of classical antitumor drugs with brassinosteroids in overcoming the negative effects of chemotherapy by reducing their effective doses.
Highlights
In this work, the effect of brassinosteroids on the antitumor activity of classical cytostatic cisplatin in tumor cell lines A549 and Hep G2 was evaluated
The results suggest a possible benefit of combinations of classical antitumor drugs with brassinosteroids in overcoming the negative effects of chemotherapy by reducing their effective doses
Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids / P
Summary
Институт биоорганической химии Национальной академии наук Беларуси, Минск, Республика Беларусь. Влияние комбинации цисплатина с брассиностероидами на рост раковых клеток Аннотация. Изучено влияние природных брассиностероидов 24-эпибрассинолида и 28-гомокастастерона, а так же их синтетических аналогов (22S,23S)-24-эпибрассинолида и (22S,23S)-28-гомокастастерона на противоопухолевую активность классического цитостатика цисплатина на опухолевых линиях A549 (карцинома легких человека) и Hep G2 (карцинома печени человека). Все четыре соединения в сочетании с цисплатином ингибировали рост раковых клеток. Более эффективными были комбинации с низкими концентрациями синтетических брассиностероидов. При концентрации брассиностероидов в 1 мкМ IC50 цисплатина уменьшалась почти в 2 раза. Ключевые слова: брассиностероиды, цисплатин, антипролиферативная активность, Hep G2, A549 Для цитирования: Панибрат, О. В. Влияние комбинации цисплатина с брассиностероидами на рост раковых клеток / О. EFFECT OF COMBINATION OF CISPLATIN WITH BRASSINOSTEROIDS ON THE GROWTH OF CANCER CELLS
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