Abstract

The French RCT CLOSE demonstrated that patients having experienced cryptogenic stroke and having a patent foramen ovale (PFO) with echocardiographic features representing risk of stroke benefited from PFO closure compared to antiplatelet therapy. This analysis determines the cost-effectiveness from the perspective of the French healthcare system of percutaneous PFO closure in combination with antiplatelet therapy versus antiplatelet therapy alone using economic data collected during the CLOSE trial.

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