Abstract

Patients with recurrent/metastatic head and neck cancer (R/M SCCHN) may be treated with sequences starting with cetuximab (Cet) regimens (EXTREME /TPEx) followed by nivolumab, or cisplatin/carboplatin + fluorouracil (CT) + pembrolizumab followed by chemotherapy and/or Cet. The sequences starting with Cet schemes represent the therapeutic alternatives with the longest overall survival (OS) published to date in R/M SCCHN. Sequences starting with EXTREME (Cet + CT)) yielded a median OS of 19.4 months, and those starting with TPEx (Cet + cisplatin + docetaxel + granulocyte colony-stimulating factor) achieved 21.9 months.

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