EE3 Cost Estimation of Published Heart Failure and Edema Events in Hyperkalemic Patients on Patiromer and Sodium Zirconium Cyclosilicate

Abstract

Risk of real-world hospitalizations for heart failure (HHF), and edema hospitalizations or emergency department (ED) visits (edema events) were previously directly compared by Zhuo et al (J Card Fail 2022;28:1414–23) for patients on patiromer (PAT) or sodium zirconium cyclosilicate (SZC), and showed consistent numerical differences across all endpoints favoring PAT. Statistical significance was achieved on the secondary endpoint of edema events and in a subgroup of patients who did not have HF prior to index HHF event. These numeric differences warrant further investigation as they may have economic and/or clinical importance.