EE268 Budget Impact Analysis for the Use of Sodium Phenylacetate and Sodium Benzoate in the Treatment of Acute Hyperammonemia: Experience in a Saudi Setting

Abstract

Sodium phenylacetate/Sodium benzoate injection combination is an orphan drug indicated as an adjunct therapy in treating acute Hyperammonemia and associated encephalopathy in patients with urea cycle enzyme deficiencies. There is a lack of economic data on its use in the pediatric population, particularly in Saudi Arabia. This analysis aims to assess the budget impact of Sodium phenylacetate and Sodium benzoate injection combination in treating acute Hyperammonemia and associated encephalopathy in patients with urea cycle enzyme deficiencies compared to hemodialysis in the pediatric population.