Abstract
Single-arm trials (SAT) have been increasingly used to support oncology reimbursement submissions worldwide. In a previous study, the authors assessed the use of SAT-based oncology technical appraisals by the National Institute for Health and Care Excellence (NICE) from 2017 to 2022, approach to generate comparative evidence, and recommendations from committee reviews. The objective of this study was to assess the use of SATs in Canadian Agency for Drugs and Technologies in Health (CADTH) reviews of oncology drugs.
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