EE147 Estimating the Causal Effect of Early Use of Erythropoietic Stimulating Agents in Intermediate-1 to Low-Risk MDS Patients: An Application of the Longitudinal Targeted Maximum Likelihood Estimation

Y Zhang,N Kreif,V Gc,A Bennett,A Manca

doi:10.1016/j.jval.2022.09.399

EE147 Estimating the Causal Effect of Early Use of Erythropoietic Stimulating Agents in Intermediate-1 to Low-Risk MDS Patients: An Application of the Longitudinal Targeted Maximum Likelihood Estimation

Y Zhang, N Kreif + Show 3 more

https://doi.org/10.1016/j.jval.2022.09.399

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Journal: Value in Health

Publication Date: Dec 1, 2022

Affiliation: University of York

#Longitudinal Targeted Maximum Likelihood Estimation #Effect Of Early Use + Show 8 more

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Abstract

To demonstrate the use of Longitudinal Targeted Maximum Likelihood Estimation (LTMLE) methods to derive causal average treatment effect estimates for survival and health-related quality of life (measured by the EQ5D) outcomes from longitudinal real-world data with risk of bias from immortal-time and time-varying confounding.

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