Abstract

Multi-cancer early detection (MCED) testing along with standard of care (SoC) could improve survival outcomes and lower treatment costs but increase screening costs. These estimates may depend on methods for projecting post-diagnosis survival. Mixture Cure Modeling (MCM) has been proposed for projecting survival impact with MCED tests because it includes a proportion of cured patients which is less sensitive to lead time bias. This study explores the impact of using MCM vs a simple extrapolation of survival on the cost-effectiveness of MCED testing.

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