Editors' Selections from Relevant Scientific Publications

Abstract

Highlights from the Literature| June 01 2023 Editors' Selections from Relevant Scientific Publications Author & Article Information Online ISSN: 1940-6215 Print ISSN: 1940-6207 ©2023 American Association for Cancer Research2023American Association for Cancer Research Cancer Prev Res (Phila) (2023) 16 (6): 303. https://doi.org/10.1158/1940-6207.CAPR-16-6-HFL Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record June 1 2023 Citation Editors' Selections from Relevant Scientific Publications. Cancer Prev Res (Phila) 1 June 2023; 16 (6): 303. https://doi.org/10.1158/1940-6207.CAPR-16-6-HFL Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Obese adipose tissue in the mammary gland (by Arendt et al. via Cancer Research Bhardwaj et al. investigated whether high body mass index (BMI) increases breast cancer risks for women carrying BRCA 1 or BRCA2 mutations. They examined noncancerous breast tissue from 69 such women and found that BMI and biomarkers of metabolic dysfunction were positively correlated with DNA damage in epithelia. RNA sequencing data revealed that obesity altered breast adipose microenvironment and activated estrogen biosynthesis. Blocking signaling pathways mediated by either estrogen or obesity-associated factors leptin or insulin, reduced DNA damage. Additionally, a high-fat diet increased DNA damage and mammary tumors in Brca1+/−mice. These results provide mechanistic insight linking obesity and breast cancer in BRCA mutation carriers, and suggest that reducing risk may involve maintaining a lower body weight, addressing metabolic problems and targeting estrogen. Bhardwaj P, … Brown KA. Sci Transl Med. 2023 Feb 22;15(684):eade1857.... You do not currently have access to this content.