Abstract
In “Body composition status and the risk of migraine: A meta-analysis,” Gelaye et al. reported that a meta-analysis of 12 studies revealed that the risk of migraine is increased in persons who are underweight. Dr. Gupta attributes the fact that this finding was statistically significant to the methodology of the meta-analysis, rather than to a true relationship, noting that he does not believe uncomplicated low body mass index (BMI) is associated with migraine. In support of this conclusion, he remarks that (1) Addison disease, a disorder that causes low body weight, is not associated with migraine; and (2) thyrotoxicosis, which also leads to low body weight, is associated with cephalgias of unclear etiology. Gelaye et al. respond that they were unsurprised by the relationship they observed between low BMI and migraine. They support the validity of their finding by noting that migraine is associated with altered levels of adipocytokines and that, correspondingly, their meta-analysis also showed an association between obesity and migraine. In “Body composition status and the risk of migraine: A meta-analysis,” Gelaye et al. reported that a meta-analysis of 12 studies revealed that the risk of migraine is increased in persons who are underweight. Dr. Gupta attributes the fact that this finding was statistically significant to the methodology of the meta-analysis, rather than to a true relationship, noting that he does not believe uncomplicated low body mass index (BMI) is associated with migraine.
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