Editorial: Variation in Phase II Metabolism of Sex Steroids - Causes and Consequences.

Jenny Jakobsson Schulze,Lena Ekström

doi:10.3389/fendo.2015.00050

Jenny Jakobsson Schulze, Lena Ekström

Open Access

https://doi.org/10.3389/fendo.2015.00050

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Journal: Frontier in Endocrinology	Publication Date: Apr 28, 2015
Citations: 1	License type: cc-by

Affiliation: Karolinska Institutet

Abstract

Phase II metabolism, usually known as conjugation reactions, generate metabolites that are, in most cases, biologically inactive and subsequently excreted in bile or urine. Androgenic and estrogenic sex steroids are mainly inactivated by sulfation or glucuronidation by the enzyme families’ sulfotransferases (SULTs) or uridine diphospho glucuronosyltransferases (UGTs). Genetic variations in UGTs and SULTs have been implicated to play a role in hormonedependent diseases and in the outcome for doping test results. Moreover, the use of drugs may interact with UGTs and SULTs and hence affect the phase II metabolism. The aim of this research topic forum was to highlight the progress made in this field via review papers and original articles as well as to promote future research with the aim to further understand the consequences of inter-individual difference in phase II metabolism and regulation

Highlights

Eight articles are included in this Research Topic, of which three are reviews and five are original research articles
In the original article written by Bang et al (1), the UGT2B17 deletion polymorphism impact on testosterone replacement therapy was studied
In the article by Strahm et al (2), it was shown that a well characterized single nucleotide polymorphism in UGT2B15 is associated with the glucurunidation activity of 19-noradrosterone, the nandrolone metabolite analyzed at the WADA accredited doping labs

Summary

Introduction

Eight articles are included in this Research Topic, of which three are reviews and five are original research articles. In the original article written by Bang et al (1), the UGT2B17 deletion polymorphism impact on testosterone replacement therapy was studied. Testosterone is being therapeutically used and a common drug together with synthetic androgens, i.e., nandrolone to abuse (doping).

Results

Conclusion