Abstract
Editorial: The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance.
Highlights
The focus of this Research Topic is to bring new insights into central immune tolerance
Much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene [1,2,3], the main thymus cell type that expresses this gene, and the medullary thymic epithelial cells [4, 5]
They focused on the posttranscriptional control of promiscuous gene expression (PGE) by miRNAs as well as epigenetic control involving DNA methylation, histone modifications, and topology of chromosomes
Summary
The focus of this Research Topic is to bring new insights into central immune tolerance. Much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene [1,2,3], the main thymus cell type that expresses this gene, and the medullary thymic epithelial cells (mTECs) [4, 5].
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