Abstract
Editorial: The emerging discipline of quantitative systems pharmacology.
Highlights
Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry
In the present research topic entitled, “The Emerging Discipline of Quantitative Systems Pharmacology,” we provide an introduction to the developing field of QSP with a series of articles that describe models in different disease areas; showing how these models can be used to evaluate important research questions in pharmaceutical R&D
The research topic starts with a perspective article by Leil and Bertz (2014) that describes the history of how modeling tools where used in pharmacology and in drug development
Summary
Quantitative Systems Pharmacology (QSP) has emerged recently as an approach that integrates knowledge coming from multiple disciplines including drug pharmacology, systems biology, physiology, mathematics and biochemistry. QSP models are typically perceived as a research tool for hypothesis generation in drug discovery and exploratory clinical development; recently the US FDA used a QSP model to evaluate a proposed drug regimen for a new biologic therapy (Peterson and Riggs, 2015).
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