Abstract
Editorial: Sensing DNA in Antiviral Innate Immunity.
Highlights
The editorial team welcomes you to the specific Research Topic on “Sensing DNA in Antiviral Innate Immunity”
The authors showed the structures of endosomal and cytosolic DNA sensors alone or complexed with DNA to provide insights on how binding the DNA to these sensors triggers the signaling pathways to activate the antiviral immune responses. They focused on the endosomal DNA sensor TLR9 and multiple cytosolic DNA sensors, including cyclic GMP-AMP synthase (cGAS), interferon-gamma inducible protein 16 (IFI16), absent in melanoma 2 (AIM2), and DNA-dependent activator interferon regulatory factor (IRF) (DAI)
He provided an update on the role of stimulator of interferon genes (STING) trafficking and polymerization in cGAS-STING signaling, how cellular proteins involve in cGASSTING activation, and the evasion of cGAS-STING signaling by DNA viruses
Summary
The editorial team welcomes you to the specific Research Topic on “Sensing DNA in Antiviral Innate Immunity”. Editorial: Sensing DNA in Antiviral Innate Immunity. Central to antiviral innate immune responses is the detection of evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs) [1].
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