Abstract
Editorial: RNA Localization and Localized Translation in Neurons
Highlights
In this collection of reviews focused on “RNA Localization and Localized Translation in Neurons,” several aspects of RNA metabolism that are critical for localized RNA regulation are discussed
From transcription to transport and compartment-specific regulation, these reviews highlight the many knowns and unknowns of how local RNA regulation contributes to neuron function, how it is dysregulated in neurological diseases, and how emerging tools and technologies are revolutionizing our understanding of the functional roles local RNA regulation plays in neurons
What remains to be directly tested is whether these molecular changes in response to RNA binding proteins (RBPs) mutations or loss drive neurological diseases through dysregulation of the local transcriptome or if these are secondary to other cellular adaptations
Summary
Due to the cell-type diversity and specialized morphology and physiology of neurons, much remains to be uncovered about how local RNA regulation and translation influence neuronal function. In this collection of reviews focused on “RNA Localization and Localized Translation in Neurons,” several aspects of RNA metabolism that are critical for localized RNA regulation are discussed. From transcription to transport and compartment-specific regulation, these reviews highlight the many knowns and unknowns of how local RNA regulation contributes to neuron function, how it is dysregulated in neurological diseases, and how emerging tools and technologies are revolutionizing our understanding of the functional roles local RNA regulation plays in neurons.
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