Abstract
Editorial: Redox Regulation in Skeletal Muscle Aging and Exercise.
Highlights
MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Aging, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
The metabolic and structural changes induced by exercise affect the contractile properties of the muscle fiber
An attractive mechanism for the redox regulation of numerous cellular processes is a redox signaling relay from cytoplasmic generation to a mitochondrial response, through the sequential modification of specific residues in regulatory proteins located in close proximity to the sites of endogenously generated ROS/RNS (McDonagh et al, 2014)
Summary
Redox Regulation in Skeletal Muscle Aging and Exercise The species, concentration and cellular location of endogenously generated ROS/RNS can directly and indirectly affect the activity of redox regulated proteins and transcription factors with a multitude of downstream effects. An attractive mechanism for the redox regulation of numerous cellular processes is a redox signaling relay from cytoplasmic generation to a mitochondrial response, through the sequential modification of specific residues in regulatory proteins located in close proximity to the sites of endogenously generated ROS/RNS (McDonagh et al, 2014).
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