Abstract
Editorial: Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases.
Highlights
Specialty section: This article was submitted to Pharmacology of Ion Channels and Channelopathies, a section of the journal Frontiers in Pharmacology
The MTSET inhibition of these cysteine mutants was well-correlated with the steady-state availability of the MTSET-modified channels, suggesting a link between fast inactivation and MTSET inhibition
MTSET modification of I1770C mutant disrupted fast inactivation, in agreement with the suggested contribution of the intracellular end of DIVS6 to the inactivation gate binding site. These data indicate that the docking of the inactivation gate induces a localized conformational change that regulates the aqueous accessibility of residues situated near the C-terminus of DIVS6
Summary
Specialty section: This article was submitted to Pharmacology of Ion Channels and Channelopathies, a section of the journal Frontiers in Pharmacology. Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases Editorial: Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases.
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