Abstract
Editorial perspective of the Research Topic “Deciphering serotonin's role in neurodevelopment”
Highlights
In this Research Topic entitled “Deciphering serotonin’s role in neurodevelopment” we, together with leaders in the field, have brought together the most recent insights in serotonin’s diverse roles especially during development, by means of both reviews and new empirical data. (Smidt and van Hooft, 2013) provide an overview of the development of the serotonergic system in rodents
It was found that whereas the dorsal raphe serotonergic outgrowing neurites remained unaffected by the loss of 5-HTT, the median raphe serotonergic neurites switched from a strong repulsive toward an attractive interaction when cocultured with the medial prefrontal cortex (mPFC)
As reviewed by Kinast et al (2013) the cognitive (PFCdependent) and somatosensory phenotypes observed in 5-HTT knockout rodents as well as human subjects carrying the low activity variant of the serotonin transporter linked polymorphic region (5-HTTLPR) strikingly resemble those seen in autistic patients, rats prenatally treated with VPA, and human and rodent subjects prenatally exposed to selective serotonin reuptake inhibitor (SSRI)
Summary
In this Research Topic entitled “Deciphering serotonin’s role in neurodevelopment” we, together with leaders in the field, have brought together the most recent insights in serotonin’s diverse roles especially during development, by means of both reviews and new empirical data. (Smidt and van Hooft, 2013) provide an overview of the development of the serotonergic system in rodents. Local synthesis within the raphe nuclei is not the only source for serotonin during embryonic brain development.
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