Abstract
Editorial perspective of the Research Topic “Deciphering serotonin's role in neurodevelopment”
Highlights
In this Research Topic entitled “Deciphering serotonin’s role in neurodevelopment” we, together with leaders in the field, have brought together the most recent insights in serotonin’s diverse roles especially during development, by means of both reviews and new empirical data. (Smidt and van Hooft, 2013) provide an overview of the development of the serotonergic system in rodents
It was found that whereas the dorsal raphe serotonergic outgrowing neurites remained unaffected by the loss of 5-HTT, the median raphe serotonergic neurites switched from a strong repulsive toward an attractive interaction when cocultured with the medial prefrontal cortex (mPFC)
As reviewed by Kinast et al (2013) the cognitive (PFCdependent) and somatosensory phenotypes observed in 5-HTT knockout rodents as well as human subjects carrying the low activity variant of the serotonin transporter linked polymorphic region (5-HTTLPR) strikingly resemble those seen in autistic patients, rats prenatally treated with VPA, and human and rodent subjects prenatally exposed to selective serotonin reuptake inhibitor (SSRI)
Summary
In this Research Topic entitled “Deciphering serotonin’s role in neurodevelopment” we, together with leaders in the field, have brought together the most recent insights in serotonin’s diverse roles especially during development, by means of both reviews and new empirical data. (Smidt and van Hooft, 2013) provide an overview of the development of the serotonergic system in rodents. Local synthesis within the raphe nuclei is not the only source for serotonin during embryonic brain development.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.