Abstract
Editorial: New therapeutic targets for human placental angiogenesis disease.
Highlights
Impaired placental angiogenesis has been implicated in the pathophysiology of pregnancy complications which have immediate and long-lasting effects on the mother and her child; such complications include fetal growth restriction and macrosomia as well as pre-eclampsia and gestational diabetes
The authors highlight the implications of a prolonged hypoxic environment in inducing adaptive responses of the placenta in pregnancies at high altitude, or in the development of placental vascular pathologies such as those observed during intrauterine growth restriction and pre-eclampsia
Impaired remodeling of maternal spiral arteries by invasive placental trophoblast is thought to be the primary cause of intrauterine hypoxia and the pathophysiology of pre-eclampsia and/or intrauterine growth restriction
Summary
Impaired placental angiogenesis has been implicated in the pathophysiology of pregnancy complications which have immediate and long-lasting effects on the mother and her child; such complications include fetal growth restriction and macrosomia as well as pre-eclampsia and gestational diabetes. Therapies for improving placental angiogenesis in pathological pregnancies have not been directly tested in humans and the aim of this Research Topic in Frontiers is to highlight potential therapeutic targets.
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