Abstract
Editorial: Natriuretic Hormones.
Highlights
Specialty section: This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology
The link between renal sodium excretion and body fluid volumes has been a topic of interest since the early days of renal physiology [1]
A “third factor” was discovered when de Wardener and colleagues showed that volume expansion natriuresis still occurred in dogs given supramaximal doses of mineralocorticoids and without an increase in Glomerular filtration rate (GFR) [2]. de Wardener et al suggested that the natriuresis was due to a “natriuretic hormone” (NH), launching a new field of investigation
Summary
Specialty section: This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology. Glomerular filtration rate (GFR) and aldosterone were the first two controllers of renal sodium excretion to be recognized. NH was defined as a compound that circulates in blood, the level of which is regulated appropriately by changes in sodium and water balance.
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