Abstract
Editorial: Metals and neurodegeneration: restoring the balance.
Highlights
There is considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s (AD), Parkinson’s (PD), prion, and motor neuron diseases
These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. In this Research Topic, Metals and Neurodegeneration: Restoring the Balance, we probe the biochemical basis of metal-mediated neurodegeneration, examine genetic links between metal dyshomeostasis and brain disorders, investigate metal trafficking and metalsynaptic interactions, and their role in neurodegeneration, and examine some of the key new approaches to understanding how metals drive neurodegenerative changes
Expanding on Fe in neurodegeneration is the review by Muhoberac and Vidal (2013), who explore the genetic basis of Fe dyshomeostasis in hereditary ferritinopathy
Summary
There is considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s (AD), Parkinson’s (PD), prion, and motor neuron diseases. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
