Abstract
Editorial: Memory T Cells: Effectors, Regulators, and Implications for Transplant Tolerance.
Highlights
The Editorial on the Research Topic Memory T Cells: Effectors, Regulators, and Implications for Transplant Tolerance
It is likely that blocking B7–CD28 is insufficient for preventing allograft rejection in the face of memory T-cells
Selectively targeting CD28 with FR104 is more potent in suppression of allograft rejection than targeting CD80/86 with CTLA4-Ig (Ville et al.), suggesting that selective blockade of CD28 signaling alone presents an advantage of allowing immunoregulatory signals mediated by CTLA4
Summary
The Editorial on the Research Topic Memory T Cells: Effectors, Regulators, and Implications for Transplant Tolerance. Mounting evidence has demonstrated that memory CD8+CD122+ T-cells with central memory cell phenotypes (CD45RA−CD44highCD62LhighCCR7+) can regulate T-cell homeostasis and suppress both autoimmune and alloimmune responses. This research topic may shed light on when they act as memory versus Treg cells, and how to target memory T-cells or otherwise utilize memory-like Tregs to promote long-term allograft survival.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
