Editorial: Macrophage Metabolism and Immune Responses.

Héctor Rodríguez,Rafael Prados-Rosales,José Luis Lavín,Juan Anguita,Massimiliano Mazzone

doi:10.3389/fimmu.2020.01078

Abstract

Funded by grants from the Ministry of Science and Innovation (MCI) co-financed with FEDER funds (RTI2018-096494-B-100 to JA and SAF2016-77433-R to RP-R). MM is supported by an ERC Consolidator grant (acronym: ImmunoFit; #773208). RP-R is a Ramon y Cajal Fellow from the MCI. We thank the MCI for the Severo Ochoa Excellence accreditation (SEV-2016-0644).

Highlights

Macrophages are key components of the immune response to infectious organisms, with a dual role eliminating infectious agents by phagocytosis while mediating defensive and inflammatory pathways
New evidence suggests that the metabolic status and specific metabolic pathways are instrumental for the modulation of macrophage responses to the ever-changing environment that these cells face in vivo
To clarify the observed susceptibility to infection of bone marrow macrophages (BMMs) from CBA mice by two species of Leishmania, Bezerra de Menezes et al, performed a differential proteomic analysis of infected macrophages and found that host responses related to oxidative stress and iron metabolism might dictate the intracellular fate of this pathogen

Summary

Introduction

Macrophages are key components of the immune response to infectious organisms, with a dual role eliminating infectious agents by phagocytosis while mediating defensive and inflammatory pathways. (2020) Editorial: Macrophage Metabolism and Immune Responses. New evidence suggests that the metabolic status and specific metabolic pathways are instrumental for the modulation of macrophage responses to the ever-changing environment that these cells face in vivo.

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