Abstract
Editorial: Liver Myofibroblasts.
Highlights
Specialty section: This article was submitted to Gastrointestinal Sciences, a section of the journal Frontiers in Physiology
Prominent stress fibers can be used to identify MFB in the tissue. They are of mesenchymal origin and are produced by activation and transdifferentiation of quiescent cell precursors after tissue injury. They are not found in normal liver but they appear in large numbers in damaged liver and become a major source of extracellular matrix (ECM) proteins that replace functional tissue
Based on the important role of MFB, the knowledge of the transdifferentiation process is critical to understanding the development liver fibrosis
Summary
Specialty section: This article was submitted to Gastrointestinal Sciences, a section of the journal Frontiers in Physiology. They are of mesenchymal origin and are produced by activation and transdifferentiation of quiescent cell precursors after tissue injury. MFB precursors in the liver are hepatic stellate cells (HSC), portal fibroblasts, and circulating bone marrow-derived collagen-producing cells (fibrocytes). Based on the important role of MFB, the knowledge of the transdifferentiation process is critical to understanding the development liver fibrosis.
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