Editorial: [Influence of Nutrition on Premetabolic Syndrome and Vascular Variability Syndrome

Abstract

The metabolic syndrome (MS) is a constellation of abnormalities including central obesity; glucose intolerance, and type 2 diabetes; hypertension; and a dyslipidemia characterized by increased serum triglycerides, decreased high-density lipoprotein (HDL) cholesterol, and increased small, dense low-density lipoprotein (LDL) particles [1-6]. Presence of biophysical-semeiotic constitution, and related inherited real risks evolving slowly towards relative disorders, may be defined as premetabolic syndrome. The metabolic syndrome affects more than 27% of adults in the United States [6] and increases the risk of cardiovascular disease 2- to 3-fold, but exclusively in individuals with biophysical-semeiotic constitution-dependent, inherited, coronary real risk, which has been described in the former paper on this website, thus not in all patients with MS [7-12]. More precisely speaking, all components of metabolic syndrome may occur exclusively in subjects with congenital acidosic enzyme metabolic histangiopathy (CAEMH), as well as with either or all CAEMH-dependent, biophysical-semeiotic constitutions [4, 5, 7, 9-12]. As a consequence, not all patients with metabolic syndrome are equal. Biophysical-semiotic constitution may be characterised with abnormal vasomotion in the microcirculation. I recently expressed my views [5] about the Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes [13], underscoring some important points. While some of the views were acceptable, critically important information was missing to warrant its designation as a syndrome [13]. Despite the alarming prevalence of the metabolic syndrome and the magnitude of risk it confers, defining the pathogenic links between the metabolic syndrome and cardiovascular disease, has been difficult, and whether they are united by some common underlying patho-physiology remains a matter of intense debate. It is possible that Quantum Biophysical Semeiotics can explain such relation [4, 5, 11, 12, 14, 15].