Abstract
Editorial: In silico Modeling of Brain Receptors for Antidepressants, Psychostimulants, and Other CNS-Active Drugs.
Highlights
Specialty section: This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology
The physiological binding sites for antidepressants, antipsychotics, psychostimulants, opiates, and anticonvulsants are embedded in the membranes of neurons and their vesicles. Such integral membrane proteins (IMPs) have been notoriously difficult to crystallize in situ (Bolla et al, 2012), and extracting the proteins from the membrane before crystallization may render a nonfunctional protein
Breakthroughs related to IMP structure and function have yielded high-resolution x-ray data for G protein-coupled receptors, voltage- and ligand-gated ion channels, and neurotransmitter transporter proteins
Summary
Specialty section: This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology. In silico Modeling of Brain Receptors for Antidepressants, Psychostimulants, and Other CNS-Active Drugs Receptors for Antidepressants, Psychostimulants, and Other CNS-Active Drugs.
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