Abstract
IT has been recognized for a number of years that infants with congenital T-cell defects (cellular immune deficiencies) will readily accept various allogeneic grafts. Immunologic reconstitution of these infants by transplantation of appropriate lymphoid cell lines or by restoration of normal thymic stimulation has challenged a number of investigators. However, severe and often fatal graft-versus-host (GVH) disease followed the early attempts at reconstitution when adult blood or bone-marrow donors were used who were incompatible in the HLA tissue antigen system.1 With the advent of HLA typing, it was recognized that a 25 per cent chance existed that siblings might be . . .
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