Abstract
Editorial: Immunoglobulin Therapy in the 21st Century - the Dark Side of the Moon.
Highlights
Specialty section: This article was submitted to Primary Immunodeficiencies, a section of the journal Frontiers in Immunology
It is suggested that continuously increasing immunoglobulin therapy (IG) trough levels decreases pulmonary infections and damage
Other studies on large patient cohorts found no correlation between IG trough level and the incidence of pneumonia and serious infections when trough levels were raised above 400 mg/dl [4, 5]
Summary
Specialty section: This article was submitted to Primary Immunodeficiencies, a section of the journal Frontiers in Immunology. Since its widespread introduction in the early 1980s, immunoglobulin therapy (IG) has been extensively investigated to understand its mechanism of action and clinical benefits. Dosage and other aspects of the therapeutic regimen remain open questions even in the mainstream indication of substitution therapy in PID.
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