Editorial [Hot Topic: Genetics Dissection of Complex Traits in the Genomic Era (Guest Editor: Bernardo Ordas)

Bernardo Ordas

doi:10.2174/138920212800543075

Abstract

Editorial [Hot Topic: Genetics Dissection of Complex Traits in the Genomic Era (Guest Editor: Bernardo Ordas)

Highlights

There is a renewed interest for Quantitative genetics since the genomic revolution
As explained by William Hill, one of the main practical objectives of quantitative genetics is an accurate prediction of breeding values because the rate of genetic improvement is proportional to the accuracy of those estimations
The author classifies the statistical methodologies into two main groups: Bayesian with a more or less arbitrary choice of prior distribution of gene effects and BLUP mixed models (GBLUP) which typically assume that genetic variance is distributed across all SNPs

Summary

Introduction

There is a renewed interest for Quantitative genetics since the genomic revolution. Quantitative or complex traits are those controlled by multiple genes so that the inheritance of such complex traits is non-Mendelian, each individual gene shows Mendelian inheritance. As explained by William Hill, one of the main practical objectives of quantitative genetics is an accurate prediction of breeding values because the rate of genetic improvement is proportional to the accuracy of those estimations.

Results

Conclusion