Abstract
Editorial [Hot Topic: Adenosine-Based Modulation of Brain Activity (Guest Editor: DETLEV BOISON)
Highlights
The purine ribonucleoside adenosine is an endogenous modulator of brain function uniquely positioned to integrate a wide variety of signalling pathways
Due to the advent of modern molecular tools, the adenosine-field has experienced a revival during the past decade that led to the development of experimental adenosine-based therapeutics
While the first two chapters focus on molecular mechanisms, with an emphasize on upstream and downstream pathways, respectively, the remaining review articles are devoted to the role of adenosine regulation and dysregulation within the context of specific physiological and pathophysiological conditions
Summary
The purine ribonucleoside adenosine is an endogenous modulator of brain function uniquely positioned to integrate a wide variety of signalling pathways. This Hot Topics Issue is devoted to the role of adenosine as regulator of brain activity in health and disease. Therapeutic modulation of the adenosine system holds much promise for the soft therapy of a wide variety of neurological or neuropsychiatric conditions.
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