Abstract
Editorial: Heme Oxygenases: Novel Regulators of Reproductive Processes.
Highlights
Specialty section: This article was submitted to Obstetric and Pediatric Pharmacology, a section of the journal Frontiers in Pharmacology
Using a mouse model where tolerance is induced by donor-specific transfusion and anti-CD40L, Yamashita et al (2006) observed that Heme oxygenase (HO)-1 is necessary for long-term graft tolerance as grafts do not survive in Hmox1−/− compared to WT control recipients
The immunomodulatory effect on cells from graft recipients is based on the fact that HO-1 directly modulates the phenotype of dendritic cells (DCs) (Moreau et al, 2009)
Summary
Specialty section: This article was submitted to Obstetric and Pediatric Pharmacology, a section of the journal Frontiers in Pharmacology. Edited by: Irina Burd, Johns Hopkins University School of Medicine, USA The role of HO-1 in xenograft and allograft acceptance is due to its cytoprotective properties that support cell survival and function within the transplanted organ.
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