Abstract
EDITORIAL article Front. Cell. Neurosci., 30 April 2021Sec. Cellular Neurophysiology Volume 15 - 2021 | https://doi.org/10.3389/fncel.2021.682524
Highlights
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience
Morphological organization of the CNS represents the basis for its functional properties underlying higher brain functions; efforts are needed to boost the comprehension of the organization of the CNS, from the ultrastructural to the functional-networks level
It has been hypothesized that the morpho-functional heterogeneity of astrocytes in different brain regions might explain the regional diversity of astrocytic response to an external injury and the selectivity of neuronal degeneration (Cragnolini et al, 2018, 2020)
Summary
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Glial cells, including astrocytes, oligodendrocytes, and microglia, actively participate in many complex functions within the CNS (immunity surveillance and inflammatory response, metabolic and synaptic homeostasis, modulation of blood-brain barrier—BBB) (Volterra and Meldolesi, 2005).
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