Editorial: Further Understanding of Serotonin 7 Receptors' Neuro-psycho-pharmacology.

Carla Perrone-Capano,Walter Adriani

doi:10.3389/fnbeh.2015.00307

Abstract

Editorial: Further Understanding of Serotonin 7 Receptors' Neuro-psycho-pharmacology.

Highlights

This volume assembles a number of original research articles and review papers focused on the serotonin receptor 7 (5-HT7R), the most recently described member of the serotonin receptor family
Molecular modeling and site-directed mutagenesis experiments led to the identification of essential residues, which are important for receptor-ligand binding and G-protein activation in the human 5-HT7R (Impellizzeri et al, 2015)
Speranza et al (2015), using neuronal primary cultures dissociated from various areas of the CNS, demonstrate that stimulation of 5-HT7R enhances neurite outgrowth through several signal transduction pathways, such as mTOR, the Rho GTPase Cdc42, Cdk5, and ERK: all these do converge to modulate cytoskeleton reorganization

Summary

Introduction

This volume assembles a number of original research articles and review papers focused on the serotonin receptor 7 (5-HT7R), the most recently described member of the serotonin receptor family. In vitro studies were exploited by Samarajeewa et al (2014) to show that 5-HT7R activation promotes an increase in TrkB receptor expression and phosphorylation, involving pathways downstream of both Gαs and Gα12 protein. Since TrkB is one of the receptors for BDNF, these results raise the interesting possibility that the BDNF signaling might be modulated by 5-HT7R activation in vivo.

Results

Conclusion