Abstract
Editorial for "Regulatory RNAs in the nervous system".
Highlights
Until about a decade ago, the non-coding part of the genome was considered without function
Non-coding transcripts can be divided into three broad classes: (i) short RNAs, (ii) RNAs transcribed from the opposite strand of a protein-coding locus that contain sequences antisense with respect to the protein-coding transcript, (OS-RNAs) and (iii) long intergenic non-coding RNAs
These studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory non-coding RNAs (nc-RNAs) represent novel layers of regulation
Summary
Until about a decade ago, the non-coding part of the genome was considered without function. Many of these non-coding RNAs (nc-RNAs) can regulate the transcription or the translation of protein-coding genes. These studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation.
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