Abstract
Editorial: Essential Pathways and Circuits of Autism Pathogenesis.
Highlights
Specialty section: This article was submitted to Systems Biology, a section of the journal Frontiers in Neuroscience
Three manuscripts critically review the hypothesis that the cerebellum is essential for many, if not most of the processes that are perturbed in Autism spectrum disorder (ASD), including language and communication, social interactions, stereotyped behavior, motor activity and motor coordination, and higher cognitive functions (Hampson and Blatt; D’Mello and Stoodley; Mosconi et al.)
Circuit-level explanations of ASD pathogenesis are appealing because they most directly account for the emergence of clinical symptoms; because ASD genes are expressed across the whole brain, it is at this time unclear how specific circuits, cell types and brain regions are more likely to be involved in producing symptoms
Summary
Specialty section: This article was submitted to Systems Biology, a section of the journal Frontiers in Neuroscience. Accumulating evidence suggests that, in the face of this etiological complexity, we may be able to understand the emergence of key core clinical symptoms by examining a limited number of convergent biochemical pathways or brain circuits.
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