Abstract
Editorial: DNA and RNA Metabolism Meet at Chromatin to Control Genome Stability.
Highlights
The integrity of the genome is continuously challenged by endogenous and exogenous DNA damaging agents and by lesions arising during DNA replication and transcription
To prevent the severe biological consequences that may arise from DNA injuries, cells have evolved an intricate network of genome surveillance mechanisms, collectively designated as DNA damage response (DDR)
Histone modifications are best understood for their effects on transcription, but it is becoming increasingly evident that they function in the DDR, where chromatin reorganization is required to allow access of repair proteins to DNA lesions
Summary
The integrity of the genome is continuously challenged by endogenous and exogenous DNA damaging agents and by lesions arising during DNA replication and transcription. DNA and RNA Metabolism Meet at Chromatin to Control Genome Stability Editorial: DNA and RNA Metabolism Meet at Chromatin to Control Genome
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