Abstract
Illnesses known as neurodegenerative diseases result in the death of specific brain tissue (Gammon,18 2014), such as Alzheimer's disease and Parkinson's disease. Biosignatures are associated with 19 neurodegenerative diseases (Li, et al., 2021). To date, neurodegenerative illnesses have been 20diagnosed and treated according to reliable biosignatures (Karaboğa and Sezgintürk, 2022), including 21 those obtained from neuropsychological testing (Lin and McDonough, 2022) between the pedunculopontine nucleus changed after exercise. They found that the walking exercise 81 altered the functional connection between pedunculopontine nucleus in both a dose-independent 82 (focused on the right pedunculopontine nucleus and the laterality of pedunculopontine nucleus 83 connectivity strength) and dose-dependent (focused on the left pedunculopontine nucleus) manner. 84The pedunculopontine nucleus may participate in compensatory and pathological Parkinson's disease 85 gait mechanisms.
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