Abstract
Rotator cuff tendon repair has a high failure rate due to the inferior quality of tendon material. Platelet-rich plasma (PRP) is considered a potential solution, though its clinical impact is uncertain. Recent literature indicates that while PRP may reduce re-tear rates radiologically, it does not significantly improve clinical outcomes such as pain and function. Early animal studies showed potential benefits, but initial clinical trials were inconclusive due to small sample sizes and varied PRP methods. Larger, recent studies suggest a possible benefit, yet definitive clinical advantages remain elusive. Advancing PRP research requires a dual approach: deeper understanding of tendon and PRP biology, and larger clinical trials focusing on specific PRP preparations and delivery methods. While current evidence is limited, PRP holds promise for improving rotator cuff repair outcomes, and ongoing research may eventually translate into significant clinical benefits.
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