Abstract
This small, but well-designed, nonrandomized cross-over study of oxybutynin combined with alarm therapy showed no improvement in monosymptomatic nocturnal enuresis (MNE) after the institution of anticholinergics to those without a response to alarm therapy. The families were initially allowed to choose oxybutynin or alarm therapy as monotherapy. Their results showed that 10% of those taking oxybutynin alone had a full response compared with 56% of those using alarm therapy alone. None of the patients without a response to alarm therapy became dry after initiating an appropriate dose of oxybutynin. In contrast, 33% of those without a response to oxybutynin monotherapy had a full response after the addition of alarm therapy. No differences were noted in the mean functional bladder capacity between the 2 groups. Anticholinergics Do Not Improve Cure Rate of Alarm Treatment of Monosymptomatic Nocturnal EnuresisUrologyVol. 77Issue 3PreviewTo determine whether previous anticholinergic therapy or a combination of anticholinergics and alarm treatment could increase the success rates for monosymptomatic nocturnal enuresis. Alarm treatment of monosymptomatic nocturnal enuresis is the treatment of choice, with the greatest lasting success. It has been proposed that failures are related to a patient's small bladder volume. Full-Text PDF
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