Abstract
Lower urinary tract symptoms (LUTS) and cardiovascular disease both are frequent in the general population and their prevalence increases with age. Findings in rats 1 Clemow D.B. Spitsbergen J.M. McCarty R. et al. Altered NGF regulation may link a genetic predisposition for hypertension with hyperactive voiding. J Urol. 1999; 161: 1372-1377 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar and humans, 2 Michel M.C. Heemann U. Schumacher H. et al. Association of hypertension with symptoms of benign prostatic hyperplasia. J Urol. 2004; 172: 1390-1393 Abstract Full Text Full Text PDF PubMed Scopus (99) Google Scholar including a study in this issue, 3 Wehrberger C. Temml C. Gutjahr G. et al. Is there an association between lower urinary tract symptoms and cardiovascular risk in men? A cross-sectional and longitudinal analysis. Urology. 2011; 78: 1063-1067 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar indicate that they may coexist more frequently than expected based on chance alone. A major difference is that LUTS typically impair quality of life (QoL) but cause little morbidity and mortality, whereas hypertension or atherosclerosis initially have little impact on QoL but lead to potentially disabling or even lethal events, such as myocardial infarction or stroke. Although it is unlikely that LUTS cause cardiovascular disease, it is possible that the latter can predispose for LUTS; alternatively, LUTS and cardiovascular disease may have a common causative factor, eg, sympathetic hyperactivity. In light of studies demonstrating an adverse effect of reduced tissue perfusion on lower urinary tract function, 4 Shenfeld O.Z. Meir K.S. Yutkin V. et al. Do atherosclerosis and chronic bladder ischemia really play a role in detrusor dysfunction of old age?. Urology. 2005; 65: 181-184 Abstract Full Text Full Text PDF PubMed Scopus (42) Google Scholar we propose that endothelial dysfunction and/or atherosclerosis is a cause of LUTS associated with cardiovascular disease. Is There an Association Between Lower Urinary Tract Symptoms and Cardiovascular Risk in Men? A Cross Sectional and Longitudinal AnalysisUrologyVol. 78Issue 5PreviewTo investigate the association between lower urinary tract symptoms (LUTS) and both coronary vascular disease (CVD) and stroke in men in a cross-sectional and longitudinal setting. Full-Text PDF
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