Abstract
DM is associated with a countless number of complications and target organ lesions, such as neuropathy and retinopathy. In addition, an increasing number of epidemiologic studies have found that DM can alter the risk of developing a variety of cancers. 1 Adami H.O. McLaughlin J. Ekbom A. et al. Cancer risk in patients with diabetes mellitus. Cancer Causes Control. 1991; 2: 307-314 Crossref PubMed Scopus (296) Google Scholar , 2 Inoue M. Iwasaki M. Otani T. et al. Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med. 2006; 166: 1871-1877 Crossref PubMed Scopus (441) Google Scholar However, the link between DM and PCa remains controversial. For example, a meta-analysis of 19 studies published until 2005 showed that men with DM had a significantly decreased risk of PCa. 3 Gong Z. Neuhouser M.L. Goodman P.J. et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1977-1983 Crossref PubMed Scopus (265) Google Scholar However, several studies have shown that, in selected populations, DM is associated with worse disease, characterized by more aggressive and more advanced tumors. 4 Moreira D.M. Anderson T. Gerber L. et al. The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series. Cancer Causes Control. 2011; 22: 977-983 Crossref PubMed Scopus (15) Google Scholar , 5 Abdollah F. Briganti A. Suardi N. et al. Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy?. Prostate Cancer Prostatic Dis. 2011; 14: 74-78 Crossref PubMed Scopus (37) Google Scholar Effect of Diabetes Mellitus on High-grade Prostate Cancer Detection Among Japanese Obese Patients With Prostate-specific Antigen Less Than 10 ng/mLUrologyVol. 79Issue 6PreviewTo investigate the association of diabetes mellitus (DM) with prostate cancer (PCa) risk and grade among Japanese patients undergoing extended biopsy and to investigate how obesity modifies these relationships. Full-Text PDF ReplyUrologyVol. 79Issue 6PreviewWe would like to thank you for your constructive comments on our study and for providing us with an opportunity to further discuss the effect of the association between DM and obesity on the risk of high-grade PCa. Full-Text PDF
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