Abstract
Preservation of kidney function is a critical outcome for many patients undergoing surgery for renal cortical tumors. 1 Huang W.C. Levey A.S. Serio A.M. et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006; 7: 735-740 Abstract Full Text Full Text PDF PubMed Scopus (1294) Google Scholar It has been well documented that several factors come into play when determining postoperative kidney functional outcomes. Although many of these factors are consider nonmodifiable, such as age, sex, preoperative GFR, and renal nephrometry score, others factors are thought to be modifiable, such as ischemia type and time and volume of resected normal renal parenchyma. 2 Lane B.R. Russo P. Uzzo R.G. et al. Comparison of cold and warm ischemia during partial nephrectomy in 660 solitary kidneys reveals predominant role of nonmodifiable factors in determining ultimate renal function. J Urol. 2011; 185: 421-427 Abstract Full Text Full Text PDF PubMed Scopus (280) Google Scholar Another potential method of improving kidney function outcomes is through the use of renoprotective agents. Fenoldopam and Renal Function After Partial Nephrectomy in a Solitary Kidney: A Randomized, Blinded TrialUrologyVol. 81Issue 2PreviewTo test the hypothesis that fenoldopam administration ameliorates ischemic injury, preserving the glomerular filtration rate and serum creatinine postoperatively after partial nephrectomy in patients with a solitary kidney. Full-Text PDF ReplyUrologyVol. 81Issue 2PreviewI appreciate the editorial comments and agree with the shortcomings stated for this study using a fenoldopam infusion for 24 hours during partial solitary nephrectomy in an attempt to minimize perioperative AKI. Because of the limited number of eligible patients to approach with a solitary kidney it did take several years to conclude. The collaboration with the urologic surgeons involved was vital in being able to complete this clinical study. Full-Text PDF
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
