Abstract

The authors investigated the effect of chronic tadalafil (Td) low-dose administration on penile cavernous tissue in streptozotocin-induced diabetic rats. Low-dose Td (0.09 mg/200 g weight) was given daily for 2 months. Diabetic rats on Td showed improved cavernous organization with significant morphometric increases in the area percentage of smooth muscles and elastic tissue and a significant decrease of fibrous tissue. In addition, the Td-treated group showed enhanced erectile function compared with diabetic group.

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